| Pair Name | Piperlongumine, HSP90 inhibitors | ||
| Phytochemical Name | Piperlongumine (PubChem CID: 637858 ) | ||
| Anticancer drug Name | HSP90 inhibitors (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Piperlongumine, HSP90 inhibitors | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Endoplasmic reticulum stress | |||
| Gene Regulation | Up-regulation | Expression | ATF4 | hsa468 |
| Up-regulation | Expression | DDIT3 | hsa1649 | |
| Up-regulation | Expression | HSPA5 | hsa3309 | |
| Up-regulation | Phosphorylation | MAPK8 | hsa5599 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| RKO | Colon carcinoma | Homo sapiens (Human) | CVCL_0504 | |
| HCT 15 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0292 | |
| In Vivo Model | HCT 116 cells were injected subcutaneously into the flank of athymic BALB/c nude mice (female, five weeks old). The total number of nude mice is set to 24, based on our previous experience. | |||
| Result | Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells. Cell Death Discov. 2023 Oct 13;9(1):375. doi: 10.1038/s41420-023-01672-y. | Click |
